Randomized cross-over study of adverse reactions and cost implications of intravenous push compared with infusion of iron dextran in hemodialysis patients☆

摘要: Abstract In many dialysis centers, iron dextran is administered by intravenous infusion rather than push (the method of administration recommended in the package insert) as a possible, but unproven, means to reduce side effects. This study was performed determine whether there difference adverse reactions between these two methods. Ten iron-deficient hemodialysis patients participated randomized, cross-over 100 mg over 2 minutes (undiluted) or 30-minute during first hour hemodialysis. Patients received total four doses (two each separate sessions). Blood pressure and heart rate were monitored pre-dose at frequent intervals throughout session following dose. completed event surveys before 60 after dose prior next session. pressure, rate, survey data analyzed using Wilcoxon analysis ( P ≤ 0.05 considered significant). Seven all doses, only three (one due missed one severe diarrhea possibly related dextran), patient (due unstable clinical status). No differences blood events observed A cost-minimization compare costs administration. There no nursing time number syringes needles used However, cost savings with because tubing piggyback eliminated. Iron can be either hemodialysis, significant methods terms rate. Dialysis programs minimize changing method.