Increased prepulse inhibition and sensitization of the startle reflex in autistic children.
作者： Gitte Falcher Madsen , Niels Bilenberg , Cathriona Cantio , Bob Oranje
DOI: 10.1002/AUR.1337
关键词: Test battery 、 Prepulse inhibition 、 Psychology 、 Acoustic Startle Reflex 、 Autism 、 Sensitization 、 Psychiatry 、 Moro reflex 、 Habituation 、 Audiology 、 Schizophrenia
摘要: The relation between autism spectrum disorders (ASD) and schizophrenia is a subject of intense debate research due to evidence common neurobiological pathways in the two disorders. objective this study was explore whether deficits prepulse inhibition (PPI) startle reflex, as usually seen schizophrenic patients, can be replicated group children with ASD comparison matched neuro-typically developed (NTD) controls. An additional aim possible psychophysiological subgroups within our sample. In case-control design, 35 patients 40 NTD controls were tested test battery. PPI acoustic reflex analyzed 18 subjects 34 Habituation sensitization 23 39 trials less prestimuli (76 dB), did not display drop percentage normally found healthy addition, showed significantly increased compared Combined, results may reflect hypersensitivity sensory information ASD. observed apparent. Future should developmental course longitudinal design. Autism Res 2014, 7: 94–103. © 2013 International Society for Research, Wiley Periodicals, Inc.
sci-hub.se 参考文章(62)
Meena O'Neill, Robert S. P. Jones, Sensory-Perceptual Abnormalities in Autism: A Case for More Research?. Journal of Autism and Developmental Disorders. ,vol. 27, pp. 283- 293 ,(1997) , 10.1023/A:1025850431170
M Pecevich, M C Waldo, E Pachtman, L E Adler, R D Franks, R Freedman, Neurophysiological evidence for a defect in neuronal mechanisms involved in sensory gating in schizophrenia. Biological Psychiatry. ,vol. 17, pp. 639- 654 ,(1982)
Michael Rutter, Childhood schizophrenia reconsidered. Journal of Autism and Developmental Disorders. ,vol. 2, pp. 315- 337 ,(1972) , 10.1007/BF01537622
E. F. Walker, T. Savoie, D. Davis, Neuromotor Precursors of Schizophrenia Schizophrenia Bulletin. ,vol. 20, pp. 441- 451 ,(1994) , 10.1093/SCHBUL/20.3.441
Tim B. Ziermans, Patricia F. Schothorst, Mirjam Sprong, Maurice J.C.M. Magnée, Herman van Engeland, Chantal Kemner, Reduced prepulse inhibition as an early vulnerability marker of the psychosis prodrome in adolescence Schizophrenia Research. ,vol. 134, pp. 10- 15 ,(2012) , 10.1016/J.SCHRES.2011.10.009
Sibel Kazak Berument, Michael Rutter, Catherine Lord, Andrew Pickles, Anthony Bailey, Autism screening questionnaire: Diagnostic validity British Journal of Psychiatry. ,vol. 175, pp. 444- 451 ,(1999) , 10.1192/BJP.175.5.444
Arti Parwani, Erica J. Duncan, Elsa Bartlett, Steven H. Madonick, Toby R. Efferen, Rajive Rajan, Michael Sanfilipo, Phillip B. Chappell, Subhajit Chakravorty, Stephen Gonzenbach, Grant N. Ko, John P. Rotrosen, Impaired prepulse inhibition of acoustic startle in schizophrenia Biological Psychiatry. ,vol. 47, pp. 662- 669 ,(2000) , 10.1016/S0006-3223(99)00148-1
David L. Braff, Mark A. Geyer, Gregory A. Light, Joyce Sprock, William Perry, Kristin S. Cadenhead, Neal R. Swerdlow, Impact of prepulse characteristics on the detection of sensorimotor gating deficits in schizophrenia. Schizophrenia Research. ,vol. 49, pp. 171- 178 ,(2001) , 10.1016/S0920-9964(00)00139-0
Catherine Lord, Michael Rutter, Ann Le Couteur, Autism Diagnostic Interview-Revised: a revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disorders Journal of Autism and Developmental Disorders. ,vol. 24, pp. 659- 685 ,(1994) , 10.1007/BF02172145
David L. Braff, Sensorimotor Gating and Schizophrenia Archives of General Psychiatry. ,vol. 47, pp. 181- 188 ,(1990) , 10.1001/ARCHPSYC.1990.01810140081011