Engineering Biosynthesis Mechanisms for Diversifying Polyhydroxyalkanoates.
作者： Guo-Qiang Chen , Ivan Hajnal , Hong Wu , Li Lv , Jianwen Ye
DOI: 10.1016/J.TIBTECH.2015.07.007
关键词: Metabolic engineering 、 Polyhydroxyalkanoates 、 Functional polymers 、 Biochemistry 、 Genome editing 、 Biosynthesis 、 Biology 、 Cupriavidus 、 Fatty acid synthesis 、 Synthetic biology
摘要: Polyhydroxyalkanoates (PHA) are a family of diverse biopolyesters synthesized by bacteria. PHA diversity, as reflected its monomers, homopolymers, random and block copolymers, well functional polymers, can now be generated engineering the three basic synthesis pathways including acetoacetyl-CoA pathway, in situ fatty acid synthesis, and/or β-oxidation cycles, synthase specificity. It is possible to tailor structures via genome editing or process engineering. The increasing diversity maturing production technology should lead more focused research into their low-cost high-value applications.
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