Histoplasmosis and Blastomycosis in Solid Organ Transplant Recipients.

摘要: Histoplasmosis and blastomycosis are geographically restricted dimorphic fungi that cause infection after the conidia produced in mold phase inhaled into lungs. In lungs, at 37 °C, these organisms undergo transformation yeast phase. transplant recipients, can occur by exposure to environment, reactivation of had occurred previously been controlled host until immunosuppressive medications were given post-transplantation, finally transmission from donor organ case histoplasmosis. disseminated is common, pulmonary more likely be severe than a non-immunosuppressed person. Diagnosis has improved, allowing earlier treatment, with use rapid antigen tests performed on serum urine. Initial for all but mildest cases acute histoplasmosis, should lipid formulation amphotericin B. After clinical improvement occurred, step-down therapy itraconazole recommended total 12 months most some patients will require long-term suppressive prevent relapse disease.