Role of intracellular calcium handling in force-interval relationships of human ventricular myocardium.
作者： J K Gwathmey , M T Slawsky , R J Hajjar , G M Briggs , J P Morgan
DOI: 10.1172/JCI114611
关键词: Contraction (grammar) 、 Isometric exercise 、 Long-term potentiation 、 Stimulation 、 Myofibril 、 Aequorin 、 Internal medicine 、 Chemistry 、 Calcium 、 Calcium in biology 、 Endocrinology
摘要: Experiments were performed in human working myocardium to investigate the relationship of intracellular calcium handling and availability alterations strength contraction produced by changes stimulation rate pattern. Both control myopathic muscles exhibited potentiation peak isometric force during postextrasystolic which was associated with an increase transient. Frequency-related attenuated compared controls. This occurred despite resting amplitude transient as detected aequorin. Therefore, abnormalities contractile function frequency-related are not due decreased calcium, but more likely reflect differences myofibrillar responsiveness. Sarcolemmal influx may also contribute suggested a decrease action potential duration increasing frequency is fluctuations amplitude.
sci-hub.st 参考文章(32)
J L Garvey, E G Kranias, R J Solaro, Phosphorylation of C-protein, troponin I and phospholamban in isolated rabbit hearts Biochemical Journal. ,vol. 249, pp. 709- 714 ,(1988) , 10.1042/BJ2490709
C H Orchard, E G Lakatta, Intracellular calcium transients and developed tension in rat heart muscle. A mechanism for the negative interval-strength relationship The Journal of General Physiology. ,vol. 86, pp. 637- 651 ,(1985) , 10.1085/JGP.86.5.637
J K Gwathmey, M T Slawsky, G M Briggs, J P Morgan, Role of intracellular sodium in the regulation of intracellular calcium and contractility. Effects of DPI 201-106 on excitation-contraction coupling in human ventricular myocardium. Journal of Clinical Investigation. ,vol. 82, pp. 1592- 1605 ,(1988) , 10.1172/JCI113771
A Fabiato, F Fabiato, Effects of pH on the myofilaments and the sarcoplasmic reticulum of skinned cells from cardiace and skeletal muscles. The Journal of Physiology. ,vol. 276, pp. 233- 255 ,(1978) , 10.1113/JPHYSIOL.1978.SP012231
Z. J. Penefsky, N. M. Buckley, R. S. Litwak, Effect of temperature and calcium on force-frequency relationships in mammalian ventricular myocardium Pflügers Archiv: European Journal of Physiology. ,vol. 332, pp. 271- 282 ,(1972) , 10.1007/BF00588575
Joanne S. Ingwall, Martha F. Kramer, Michael A. Fifer, Beverly H. Lorell, Richard Shemin, William Grossman, P.D. Allen, The Creatine Kinase System in Normal and Diseased Human Myocardium The New England Journal of Medicine. ,vol. 313, pp. 1050- 1054 ,(1985) , 10.1056/NEJM198510243131704
F Urthaler, A A Walker, D N Reeves, L L Hefner, Maximal twitch tension in intact length-clamped ferret papillary muscles evoked by modified postextrasystolic potentiation. Circulation Research. ,vol. 62, pp. 65- 74 ,(1988) , 10.1161/01.RES.62.1.65
Jose Ferreira de Carvalho, N. R. Draper, H. Smith, Applied regression analysis 2nd ed. Journal of the American Statistical Association. ,vol. 76, pp. 1012- ,(1981) , 10.2307/2287608
N. M. Buckley, Z. J. Penefsky, R. S. Litwak, Comparative force-frequency relationships in human and other mammalian ventricular myocardium. Pflügers Archiv: European Journal of Physiology. ,vol. 332, pp. 259- 270 ,(1972) , 10.1007/BF00588574
M D Feldman, L Copelas, J K Gwathmey, P Phillips, S E Warren, F J Schoen, W Grossman, J P Morgan, Deficient production of cyclic AMP: Pharmacologic evidence of an important cause of contractile dysfunction in patients with end-stage heart failure Circulation. ,vol. 75, pp. 331- 339 ,(1987) , 10.1161/01.CIR.75.2.331