In vivo (19)F MRI and (19)F MRS of (19)F-labelled boronophenylalanine-fructose complex on a C6 rat glioma model to optimize boron neutron capture therapy (BNCT).
作者： Paola Porcari , Silvia Capuani , Emanuela D'Amore , Mario Lecce , Angela La Bella
DOI: 10.1088/0031-9155/53/23/021
关键词: Boronophenylalanine-fructose complex 、 Boron 、 Neutron irradiation 、 Nuclear magnetic resonance 、 In vivo 、 Chemistry 、 Magnetic resonance imaging 、 Pharmacokinetics 、 Glioma 、 Nuclear medicine 、 Neutron capture
摘要: Boron neutron capture therapy (BNCT) is a promising binary modality used to treat malignant brain gliomas. To optimize BNCT effectiveness non-invasive method needed monitor the spatial distribution of carriers in order estimate optimal timing for irradiation. In this study, vivo mapping and pharmacokinetics evaluation (19)F-labelled boronophenylalanine (BPA) were performed using (19)F magnetic resonance imaging ((19)F MRI) spectroscopy MRS). Characteristic uptake (19)F-BPA C6 glioma showed maximum at 2.5 h after compound infusion as confirmed by both images spectra acquired on blood samples collected different times infusion. This study shows ability MRI selectively map bio-distribution rat model, well providing useful perform carriers.
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