Changes in some properties of glutamate decarboxylase activity during the maturation of the brain.
作者： Ricardo Tapia , Graciela Meza-Ru�z
DOI: 10.1007/BF00966105
关键词: Enzyme 、 Homogenization (biology) 、 Glutamate decarboxylase activity 、 Glutamate receptor 、 Biology 、 Centrifugation 、 Pyridoxal 、 Internal medicine 、 Glutamate decarboxylase 、 Endocrinology 、 Pyridoxal phosphate
摘要: The sensitivity of cerebral glutamate decarboxylase (GAD) activity to hypotonic homogenization medium, centrifugation, Triton-X-100, and preincubation at 37°C was studied in the developing mouse. In newborn 5-day-old animals, GAD markedly inhibited by all these conditions. From 5 days adult age, enzyme experimental conditions used decreased progressively, with greatest change between 10th 15th days. It is concluded that form enzyme, which unstable shows a relatively high affinity for pyridoxal phosphate, substituted during maturation brain. much more stable dependent on free phosphate. implications findings regulation excitability development are discussed.
springer.com
sci-hub.se 参考文章(12)
Ricardo Tapia, The Role of γ-Aminobutyric Acid Metabolism in the Regulation of Cerebral Excitability Neurohumoral Coding of Brain Function. pp. 3- 26 ,(1974) , 10.1007/978-1-4684-3066-0_1
Ricardo Tapia, Biochemical Pharmacology of GABA in CNS Springer, Boston, MA. pp. 1- 58 ,(1975) , 10.1007/978-1-4684-3174-2_1
E. Roberts, P. J. Harman, S. Frankel, gamma Aminobutyric acid content and glutamic decarboxylase activity in developing mouse brain. Experimental Biology and Medicine. ,vol. 78, pp. 799- 803 ,(1951) , 10.3181/00379727-78-19224
Margaret A. Lennox-Buchthal, Febrile convulsions;: A reappraisal, ,(1973)
Ricardo Tapia, J. Awapara, Effects of various substituted hydrazones and hydrazines of pyridoxal-5'-phosphate on brain glutamate decarboxylase. Biochemical Pharmacology. ,vol. 18, pp. 145- 152 ,(1969) , 10.1016/0006-2952(69)90019-7
R. Tapia, María-Elena Sandoval, P. Contreras, Evidence for a role of glutamate decarboxylase activity as a regulatory mechanism of cerebral excitability Journal of Neurochemistry. ,vol. 24, pp. 1283- 1285 ,(1975) , 10.1111/J.1471-4159.1975.TB03915.X
Ricardo Tapia, Graciela Meza-Ruíz, Differences in some properties of newborn and adult brain glutamate decarboxylase. Journal of Neurobiology. ,vol. 6, pp. 171- 181 ,(1975) , 10.1002/NEU.480060205
H. Ferngren, Further Studies on Chemically Induced Seizures and their Antagonism by Anticonvulsants During Postnatal Development in the Mouse Pharmacology & Toxicology. ,vol. 26, pp. 177- 188 ,(2009) , 10.1111/J.1600-0773.1968.TB00436.X
Ricardo Tapia, Herminia Pasantes-Morales, Efrain Taborda, Miguel P�rez de la Mora, Seizure susceptibility in the developing mouse and its relationship to glutamate decarboxylase and pyridoxal phosphate in brain. Journal of Neurobiology. ,vol. 6, pp. 159- 170 ,(1975) , 10.1002/NEU.480060204
W.M. Fox, Reflex-ontogeny and behavioural development of the mouse Animal Behaviour. ,vol. 13, pp. 234- IN5 ,(1965) , 10.1016/0003-3472(65)90041-2