Testing of some benzidine analogues for microsomal activation to bacterial mutagens

摘要: Summary Analogues of benzidine were assayed for mutagenic activity towards Salmonella typhimurium TA 1538 in the presence and absence a liver enzyme preparation. Purified 3,3′-dichlorobenzidine technical grade material had some direct activity, but this was increased over 50-fold by addition mixed function oxidase In preparation, approximately 10 times more active than benzidine, while 3, 3′, 5,5′-tetrafluorobenzidine equipotency. On other hand, 3,3′, 5,5′-tetramethyl-benzidine no alone or conjunction with 3,3′-Dianisidine slight none its absence.