Effects of galanin on 5-HT neurons in the rat CNS.
作者： E. Sundström , T. Melander
DOI: 10.1016/0014-2999(88)90310-X
关键词: Biology 、 Endocrinology 、 Internal medicine 、 Central nervous system 、 Galanin 、 Median eminence 、 5-Hydroxyindoleacetic acid 、 Neurotransmission 、 5-HT receptor 、 Hippocampus 、 Neuropeptide
摘要: Intraventricular injections of the neuropeptide galanin were shown to induce a significant increase endogenous 5-hydroxyindoleacetic acid (5-HIAA) levels in occipital cortex, hippocampus and median eminence rats. A general, but most regions non-significant, tendency for increased 5-hydroxytryptamine (5-HT) was also observed. In view similar effects on 3,4-dihydroxyphenylacetic (DOPAC) pons-medulla previous vitro studies, these results are compatible with presynaptic inhibitory effect certain central 5-HT neurons rat.
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