Anxiolytic-like action of centrally administered galanin
作者： Ola Bing , Christian Möller , Jörgen A. Engel , Bo Söderpalm , Markus Heilig
DOI: 10.1016/0304-3940(93)90846-D
关键词: Galanin 、 Anxiolytic like 、 Psychology 、 Emotionality 、 Anxiety 、 Animal model 、 Neuropeptide Y receptor 、 Endocrinology 、 Neuropeptide 、 Central nervous system 、 Internal medicine
摘要: The neuropeptide galanin is present in limbic brain areas important for emotionality. We examined whether central may be involved mechanisms of anxiety. Rats were tested a pharmacologically validated animal model anxiety, the Vogel punished drinking test. A 100% increase responding was seen after 3 nmol i.c.v. After 15 nmol, signs sedation seen, and no could observed. Drinking motivation, shock thresholds exploratory locomotor activity not affected by galanin. These results support specific anxiolytic-like action galanin, similar to that functionally related peptide, Y.
sci-hub.se 参考文章(26)
Tamas Bartfai, Gilberto Fisone, Ülo Langel, Galanin and galanin antagonists: molecular and biochemical perspectives. Trends in Pharmacological Sciences. ,vol. 13, pp. 312- 317 ,(1992) , 10.1016/0165-6147(92)90098-Q
Kazuhiko Tatemoto, Åke Rökaeus, Hans Jörnvall, Thomas J. McDonald, Viktor Mutt, Galanin — a novel biologically active peptide from porcine intestine FEBS Letters. ,vol. 164, pp. 124- 128 ,(1983) , 10.1016/0014-5793(83)80033-7
E. Sundström, T. Melander, Effects of galanin on 5-HT neurons in the rat CNS. European Journal of Pharmacology. ,vol. 146, pp. 327- 329 ,(1988) , 10.1016/0014-2999(88)90310-X
Tor Melander, Tomas Hökfelt, Ake Rökaeus, Distribution of galaninlike immunoreactivity in the rat central nervous system Journal of Comparative Neurology. ,vol. 248, pp. 475- 517 ,(1986) , 10.1002/CNE.902480404
B. Söderpalm, S. Hjorth, J.A. Engel, Effects of 5-HT1A receptor agonists and L-5-HTP in Montgomery's conflict test. Pharmacology, Biochemistry and Behavior. ,vol. 32, pp. 259- 265 ,(1989) , 10.1016/0091-3057(89)90242-6
M. Heilig, E. Widerlöv, Neuropeptide Y: an overview of central distribution, functional aspects, and possible involvement in neuropsychiatric illnesses. Acta Psychiatrica Scandinavica. ,vol. 82, pp. 95- 114 ,(1990) , 10.1111/J.1600-0447.1990.TB01366.X
Markus Heilig, Sarah McLeod, Michelle Brot, Steven C. Heinrichs, Frederique Menzaghi, George F. Koob, Karen T. Britton, Anxiolytic-like action of neuropeptide Y: mediation by Y1 receptors in amygdala, and dissociation from food intake effects. Neuropsychopharmacology. ,vol. 8, pp. 357- 363 ,(1993) , 10.1038/NPP.1993.35
V.R. Holets, T. Hökfelt, Å Rökaeus, L. Terenius, M. Goldstein, Locus coeruleus neurons in the rat containing neuropeptide Y, tyrosine hydroxylase or galanin and their efferent projections to the spinal cord, cerebral cortex and hypothalamus Neuroscience. ,vol. 24, pp. 893- 906 ,(1988) , 10.1016/0306-4522(88)90076-0
Sheila L. Handley, Siddika Mithani, Effects of alpha-adrenoceptor agonists and antagonists in a maze-exploration model of 'fear'-motivated behaviour. Naunyn-schmiedebergs Archives of Pharmacology. ,vol. 327, pp. 1- 5 ,(1984) , 10.1007/BF00504983
Stavroula E. Kyrkouli, B. Glenn Stanley, Sarah F. Leibowitz, Differential effects of galanin and neuropeptide Y on extracellular norepinephrine levels in the paraventricular hypothalamic nucleus of the rat: a microdialysis study Life Sciences. ,vol. 51, pp. 203- 210 ,(1992) , 10.1016/0024-3205(92)90076-2