Epidemic spread of recombinant noroviruses with four capsid types in Hungary.
作者： G REUTER , H VENNEMA , M KOOPMANS , G SZUCS
DOI: 10.1016/J.JCV.2005.07.012
关键词: Norovirus 、 Outbreak 、 Norwalk-like viruses 、 Microbiology 、 Epidemic spread 、 Recombinant DNA 、 Biology 、 Genotype 、 Transmission (medicine) 、 Capsid 、 Virology
摘要: Abstract Background Noroviruses are common pathogens in gastro-enteritis outbreaks humans worldwide. genetically diverse group of viruses with multiple genogroups (GG) and genotypes. More recently, naturally occurring recombinant noroviruses were described. These had a distinct polymerase gene sequence (designated GGIIb/Hilversum) disseminated through waterborne food-borne transmission Europe. Objectives Our aim was to characterize these emerging causing Hungary. Study design From January 2001 May 2004, samples containing “GGIIb/Hilversum polymerase” (GGIIb-pol) selected for analysis the viral capsid region (ORF2) by reverse transcription-polymerase chain reaction (RT-PCR) sequencing. Results Thirty-four (14.4%) 236 confirmed norovirus caused variant lineage GGIIb-pol. Four different recombinants detected capsids Hu/NLV/GGII/Mexico/1989 (n = 9, 43%), Hu/NLV/GGII/Snow Mountain/1976 (n = 6, 28%), Hu/NLV/GGII/Hawaii/1971 (n = 4, 19%) Hu/NLV/GGII/Lordsdale/1993 (n = 1, 5%). Conclusions In Hungary, became second most variants—next GGII-4/Lordsdale virus—causing epidemics gastroenteritis last 4 years.
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