Impact of smoking status and pathologic type on epidermal growth factor receptor mutations in lung cancer.

摘要: Background Epidermal growth factor receptor (EGFR) mutations in lung carcinomas can make the disease more responsive to treatment with tyrosine kinase inhibitors. We aimed evaluate prevalence of EGFR a large series carcinomas. Methods examined 1195 consecutive cancer patients for exons 18, 19, and 21 using direct sequencing polymerase chain reaction products. A detailed smoking history was obtained. Patients were categorized as never smokers ( 1 year ago), or current (quit <1 ago). Results There 9 (4.5%) 201 squamous carcinomas, (2%) 50 cell (2.3%) 44 small that investigated. Three hundred twenty-seven found 858 adenocarcinomas (38.1%). Among adenocarcinomas, we detected 250 (48.6%) 514 smokers, 39 (33.9%) 115 former 38 (16.6%) 229 smokers. Significantly fewer people who smoked than 15 pack-years (P=0.0002) stopped less years ago (P=0.033) compared individuals smoked. Conclusions Adenocarcinoma is most frequent mutation pathologic type cancer. The likelihood 19 decreases number increases. Mutations common cigarettes ago. These data assist clinicians assessing Chinese when mutational analysis not feasible. Chin Med J 2011;124(16):2457-2460