EGFR mutational status in a large series of Caucasian European NSCLC patients: data from daily practice

摘要: The prognosis of metastatic non-small cell lung cancer (NSCLC) is still poor. Activating epithelial growth factor receptor (EGFR) mutations are important genetic alterations with dramatic therapeutical implications. Up to now, in contrast Asian populations only limited data on the prevalence those available from patients Caucasian and especially European ethnicity. In this multicentre study, 1201 unselected NSCLC Southern Germany were tested daily clinical routine for EGFR mutation status. found 9.8% all tumours. Mutations exons 18, 19 21 accounted 4.2%, 61.9% 33.1% mutations, respectively. Non-smokers had a significantly higher rate than smokers or ex-smokers (24.4% vs 4.2%; P<0.001). Non-lepidic-non-mucinous adenocarcinomas (G2) 45.5% activating 3.5% squamous carcinomas positive. Thyroid transcription 1 protein expression was associated mutational These comprehensive add knowledge histopathological factors status NSCLC.