Epidermal growth factor receptor (EGFR) mutations are exceptionally rare in thyroid transcription factor (TTF-1)-negative adenocarcinomas of the lung

摘要: Introduction: Approximately 70% of lung adenocarcinomas express TTF-1. EGFR mutations are present in 13-15% Western adenocarcinoma patients. This paper investigates TTF1 as a negative predictor mutant adenocarcinomas. Results: In the pilot cohort (N = 301) two 224 specimens positive for had TTF-1 expression (sensitivity 99.1%, 95% confidence interval (CI) 96.8-99.9%). Estimated predictive values (NPV) mutation prevalence rates 13% and 15% 99.5% (95% credible (CRI) 98.6%99.9%) 99.4% (CRI – 98.4%-99.9%). For 15%, using validation data (211 patients), estimated NPVs were 97% CRI 92%-99%) 96% 91%-99%). Methods: Formalin-fixed paraffin-embedded tumors from patients analyzed by allele-specific PCR ‘pilot cohort’. status was documented or negative. Negative value range true (1%-50%) Bayesian modeling. The hypothesis validated separate ‘validation’ same Conclusion: An overwhelming majority will be mutations. finding allows earlier initiation chemotherapy newly diagnosed with stage IV disease.