Second Primary Cancers After Prostatic Irradiation: Ensuring an Appropriate Analysis

摘要: therapy. The hazard ratios for second cancer sites after irradiation were: rectum, 1.13 (95% confidence interval [CI], 0.98–1.31); urinary bladder, 1.23 (1.15–1.32), transverse colon, 1.14 (0.89–1.45), brain, 1.22 (0.89–1.68), lung, 1.15 (1.08–1.24); and stomach, 1.05 (0.88–1.26). When 520,708 SEER 2006 prostatic cases, with any length of followup, were similarly analyzed, none these showed increased risk. use attained age, as well Cox modeling, seems a more appropriate strategy than the analysis presented by Moon. 1 Moon’s did not incorporate an measure duration follow-up. Because malignancy risk increases older patient followed number years accumulates greater younger same period. Failure to account factors like this can lead overstatement attributable in subgroups, men irradiated cancer. finding treated transurethral resection prostate (TURP) alone may be another example this.