Incidence of Secondary Cancer Development After High-Dose Intensity-Modulated Radiotherapy and Image-Guided Brachytherapy for the Treatment of Localized Prostate Cancer

摘要: Purpose To report the incidence and excess risk of second malignancy (SM) development compared with general population after external beam radiotherapy (EBRT) brachytherapy to treat prostate cancer. Methods Materials Between 1998 2001, 1,310 patients localized cancer were treated EBRT ( n = 897) or 413). We SMs in our that extracted from National Cancer Institute's Surveillance, Epidemiology, End Results data set combined 2000 census data. The 10-year likelihood SM was 25% 15% p .02). corresponding for in-field these groups 4.9% 1.6% .24). Multivariate analysis showed vs. older age only significant predictors all .037 .030), a trend develop SM. increased explained by greater skin outside radiation field (10.6% 3.3%, respectively, .004). For group, 5- mortality rate 1.96% 5.1% out-of cancer, respectively; SM, rates 0.1% 0.7%. Among related 0.8% 2.7%, respectively. Our observed RT not significantly different population. Conclusions Using modern sophisticated treatment techniques, we low bladder rectal risks RT. Furthermore, secondary unusual. small, but increased, number cancers