Increased risk of rectal cancer after prostate radiation: A population-based study

摘要: Background & Aims: Radiation therapy for prostate cancer has been associated with an increased rate of pelvic malignancies, particularly bladder cancer. The association between radiation and colorectal not established. Methods: We conducted a retrospective cohort study using Surveillance, Epidemiology, End Results (SEER) registry data from 1973 through 1994. focused on men cancer, but no previous history treated either surgery or who survived at least 5 years. evaluated the effect development 3 sites: definitely irradiated sites (rectum), potentially (rectosigmoid, sigmoid, cecum), nonirradiated (the rest colon). Using proportional hazards model, we over time. Results: A total 30,552 received radiation, 55,263 underwent only. Colorectal cancers developed in 1437 patients: 267 sites, 686 484 sites. was independently time remainder colon. adjusted ratio rectal 1.7 group, compared surgery-only group (95% CI: 1.4–2.2). Conclusions: noted significant increase after had colon, indicating that is specific to directly tissue.