Cancer incidence after localized therapy for prostate cancer

摘要: BACKGROUND. Second cancers may occur in patients who have undergone radiation therapy. The risk for these adverse events after therapy is uncertain. In this study, the authors examined size and significance of observed association between occurrences secondary 5 years radiotherapy a large population men with incident prostate cancer. METHODS. Men cancer were identified from Surveillance, Epidemiology, End Results (SEER) registry distinguished by type treatment received, tumor stage, grade, age at diagnosis. SEER data also used to identify beginning date diagnosed cancer. Multivariate logistic regression analysis was estimate adjusted odds subsequent occurrence other associated types received surgery, patient age. RESULTS. Compared no cancer-directed radiation, external beam (EBRT) as their only form had statistically significant increased developing several sites potentially related therapy, including bladder (odds ratio [OR], 1.63; 95% confidence interval [95% CI], 1.44–1.84) rectum (OR, 1.60; CI, 1.29–1.99). Men EBRT higher upper body areas not cecum 1.10–1.70), transverse colon 1.85; 1.30–2.63), brain 1.83; 1.22–2.75), stomach 1.38; 1.09–1.75), melanoma 1.29; 1.09–1.53), lung bronchus 1.25; 1.13–1.37) compared among radioactive implants or isotopes, either isolation combined did significantly different occurring any 20 most common sites. CONCLUSIONS. Patients second both overall that exposed radiation. It noteworthy that, authors' knowledge, report shows first time despite doses delivered, lowest cancers. Cancer 2006. © 2006 American Society.