Prostatic irradiation is not associated with any measurable increase in the risk of subsequent rectal cancer

摘要: Purpose: To investigate a putative increased risk of rectal cancer subsequent to prostatic radiotherapy. Methods and Materials: In an analysis the Surveillance, Epidemiology, End Results registry, we compared men who had radiotherapy for carcinoma with those treated surgically neither modality. Kaplan-Meier analyses time failure from were performed between age-matched subgroups three cohorts. Cox proportional hazards ascertain what influences might affect incidence cancer. Results: all, 33,831 irradiated, 167,607 surgically, 36,335 received Rectal cancers developed in 243 (0.7%) irradiated (mean age, 70.7 years), 578 (0.3%) (68.7 227 (0.8%) modality (74.2 years). When age effects differences surgical untreated cohorts controlled for, unable demonstrate any significant Conclusions: An frequency after irradiation, apparent on crude analysis, could be attributed confounding other unmeasured confounders associated prostate treatment risk.