Clinical significance of TTF-1 protein expression and TTF-1 gene amplification in lung adenocarcinoma.

作者: Justine A. Barletta , Sven Perner , A. John Iafrate , Beow Y. Yeap , Barbara A. Weir

DOI: 10.1111/J.1582-4934.2008.00594.X

关键词:

摘要: The majority of lung adenocarcinomas express the lineage-specific thyroid transcription factor-1 (TTF-1). We recently reported that in a subset TTF-1 gene is amplified. Although prognostic significance expression has been previously investigated, amplification not established. studied 89 consecutive patients with treated by surgery at Brigham and Women’s Hospital between 1997 1999 performed immunohistochemical analysis for fluorescence situ hybridization amplification. investigated associations clinical–pathological characteristics, expression, overall survival. was categorized as high (48%), low (24%) or absent (28%). amplified 7% cases. Patients had significantly better outcome than those (median survival times 72.4, 77.8 30.5 months, respectively, P= 0.002). In contrast, worse if time 39.5 versus 87.5 months). multivariate analysis, improved independently predicted combination no (P < 0.001). adenocarcinoma, predictor good outcome. tend to have prognosis

参考文章(32)
Damante G, Puglisi F, Barbone F, Beltrami Ca, Bruckbauer M, Di Loreto C, Di Lauro, Prognostic value of thyroid transcription factor-1 in primary, resected, non-small cell lung carcinoma. Modern Pathology. ,vol. 12, pp. 318- 324 ,(1999)
Sven Perner, Patrick L Wagner, Francesca Demichelis, Rohit Mehra, Christopher J LaFargue, Benjamin J Moss, Stefanie Arbogast, Alex Soltermann, Walter Weder, Thomas J Giordano, David G Beer, David S Rickman, Arul M Chinnaiyan, Holger Moch, Mark A Rubin, EML4-ALK Fusion Lung Cancer: A Rare Acquired Event Neoplasia. ,vol. 10, pp. 298- 302 ,(2008) , 10.1593/NEO.07878
Nelson G. Ordóñez, John M. Lukeman, Bruce Mackay, Tumors of the lung W.B. Saunders. ,(1991)
Abida Haque, Salahuddin Syed, Subodh Lele, Daniel Freeman, Patrick Adegboyega, Immunohistochemical study of thyroid transcription factor-1 and HER2/neu in non-small cell lung cancer: strong thyroid transcription factor-1 expression predicts better survival. Applied Immunohistochemistry & Molecular Morphology. ,vol. 10, pp. 103- 109 ,(2002) , 10.1097/00022744-200206000-00002
Parviz Minoo, Guoshan Su, Hong Drum, Pablo Bringas, Shioko Kimura, Defects in tracheoesophageal and lung morphogenesis in Nkx2.1(-/-) mouse embryos. Developmental Biology. ,vol. 209, pp. 60- 71 ,(1999) , 10.1006/DBIO.1999.9234
Levi A. Garraway, Hans R. Widlund, Mark A. Rubin, Gad Getz, Aaron J. Berger, Sridhar Ramaswamy, Rameen Beroukhim, Danny A. Milner, Scott R. Granter, Jinyan Du, Charles Lee, Stephan N. Wagner, Cheng Li, Todd R. Golub, David L. Rimm, Matthew L. Meyerson, David E. Fisher, William R. Sellers, Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma Nature. ,vol. 436, pp. 117- 122 ,(2005) , 10.1038/NATURE03664
Dongfeng Tan, Qiang Li, George Deeb, Nithyia Ramnath, Harry K Slocum, John Brooks, Richard Cheney, Sam Wiseman, Timothy Anderson, Gregory Loewen, Thyroid transcription factor-1 expression prevalence and its clinical implications in non-small cell lung cancer: A high-throughput tissue microarray and immunohistochemistry study Human Pathology. ,vol. 34, pp. 597- 604 ,(2003) , 10.1016/S0046-8177(03)00180-1
Kazushige Ikeda, Jean C. Clark, Jessica R. Shaw-White, Mildred T. Stahlman, Christopher J. Boutell, Jeffrey A. Whitsett, Gene Structure and Expression of Human Thyroid Transcription Factor-1 in Respiratory Epithelial Cells Journal of Biological Chemistry. ,vol. 270, pp. 8108- 8114 ,(1995) , 10.1074/JBC.270.14.8108
Giuseppe Pelosi, Filippo Fraggetta, Felice Pasini, Patrick Maisonneuve, Angelica Sonzogni, Antonio Iannucci, Alberto Terzi, Enrica Bresaola, Francesco Valduga, Carmelo Lupo, Giuseppe Viale, Immunoreactivity for thyroid transcription factor-1 in stage I non-small cell carcinomas of the lung. The American Journal of Surgical Pathology. ,vol. 25, pp. 363- 372 ,(2001) , 10.1097/00000478-200103000-00011
F Barlési, D Pinot, A LeGoffic, C Doddoli, B Chetaille, J-P Torre, P Astoul, Positive thyroid transcription factor 1 staining strongly correlates with survival of patients with adenocarcinoma of the lung British Journal of Cancer. ,vol. 93, pp. 450- 452 ,(2005) , 10.1038/SJ.BJC.6602717