Thyroid-Specific Transcription Factors and Their Roles in Thyroid Cancer
作者： Shioko Kimura
DOI: 10.4061/2011/710213
关键词: Stem cell 、 Bioinformatics 、 FOXE1 、 Medicine 、 Thyroid 、 Transcription factor 、 Thyroid cancer 、 Tissue homeostasis 、 PAX8 、 Regulation of gene expression
摘要: Homeodomain, forkhead domain, and paired domain-containing transcription factors play a major role in development, tissue-specific gene expression, tissue homeostasis organs where they are expressed. Recently, their roles stem cell cancer biology emerging. In the thyroid, NKX2-1, FOXE1, PAX8 responsible for thyroid organogenesis expression of thyroid-specific genes critical hormone synthesis. contrast to known regulation, development homeostasis, involvement cell, and/or still elusive. order further understand nature cancer, it is determine cancer.
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