Immunoreactivity for thyroid transcription factor-1 in stage I non-small cell carcinomas of the lung.

摘要: Thyroid transcription factor-1 (TTF-1) is a nuclear protein regulating the transcriptional activity of lung-specific genes in normal and neoplastic bronchioloalveolar cells. It has been implicated growth development lung, disruption TTF-1 locus leads to neonatal death with pulmonary hypoplasia. We evaluated retrospectively prevalence clinical significance immunoreactivity 222 patients stage I non-small cell lung carcinoma (NSCLC) follow-up time at least 5 years, we investigated its relationship other markers tumor growth, namely proliferation angiogenesis. was documented by using commercially available monoclonal antibody 8G7G3/1 72% 97 adenocarcinomas, 5% 119 squamous carcinomas, glandular component two adenosquamous carcinomas. Four large carcinomas were completely unreactive. In but not correlated significantly microvessel density (p = 0.04) inversely fraction assessed Ki-67 immunostaining 0.03). Also, TTF-1-immunoreactive adenocarcinomas showed trend for size less than 3 cm 0.08). expression related specific patterns, grade, or typing. did affect patient survival, although more 75% immunoreactive cells longer overall disease-free survival. Our findings suggest that could be involved small it prognostic implications NSCLC.