Metastatic carcinoma of unknown primary: diagnostic approach using immunohistochemistry.
作者： James R. Conner , Jason L. Hornick
DOI: 10.1097/PAP.0000000000000069
关键词:
摘要: Carcinoma of unknown primary origin (CUP) is one the 10 most prevalent malignancies. CUP patients in whom a site can be ascribed have better outcomes than those which tumor remains unidentified. Among tools available to pathologists approaching these lesions, immunohistochemistry reliable, inexpensive, and widely resource. New markers continue emerge, which, combination with other historically useful antibodies, allow rapid accurate identification an increasing number cases. This review discusses approach diagnosis using outlines some particular focus on utility lineage-restricted transcription factors, including CDX2, NKX3-1, PAX8, SATB2, TTF-1, SF1.
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