LncRNA UCA1 in anti-cancer drug resistance.
作者： Haohao Wang , Zhonghai Guan , Kuifeng He , Jiong Qian , Jiang Cao
DOI: 10.18632/ONCOTARGET.18344
关键词: Oncology 、 Tamoxifen 、 Pancreatic tumor 、 Long non-coding RNA 、 Cancer 、 Clinical research 、 Drug resistance 、 Gemcitabine 、 Medicine 、 Internal medicine 、 Imatinib 、 Traditional medicine
摘要: // Haohao Wang 1, 2 , Zhonghai Guan 1 Kuifeng He Jiong Qian Jiang Cao 3 and Lisong Teng Cancer Center, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, P.R. China Key Laboratory Precision Diagnosis Treatment for Hepatobiliary Pancreatic Tumor Province, Clinical Research Second Correspondence to: Teng, email: lsteng@zju.edu.cn Keywords: long non-coding RNA, UCA1, chemoresistance, cancer Received: February 28, 2017 Accepted: May 22, Published: June 02, 2017 ABSTRACT pivotal role the RNA (lncRNA) urothelial carcinoma associated (UCA1) in anti-cancer drug resistance has been confirmed many cancers. Overexpression lncRNA UCA1 correlates with to chemotherapeutics such as cisplatin, gemcitabine, 5-FU, tamoxifen, imatinib EGFR-TKIs, whereas knockdown restores sensitivity. These studies highlight potential a diagnostic prognostic biomarker, therapeutic target malignant tumors. In this review, we address discuss its future clinical applications.
impactjournals.com参考文章(103)
Neeta Somaiah, Mary Jo Fidler, Elizabeth Garrett-Mayer, Amy Wahlquist, Keisuke Shirai, Lela Buckingham, Thomas Hensing, Philip Bonomi, George R. Simon, Epidermal growth factor receptor (EGFR) mutations are exceptionally rare in thyroid transcription factor (TTF-1)-negative adenocarcinomas of the lung Oncoscience. ,vol. 1, pp. 522- 528 ,(2014) , 10.18632/ONCOSCIENCE.72
Xin Ma, Can-Bin Zhang, Ji-Yuan Li, Overexpression of long non-coding RNA UCA1 predicts a poor prognosis in patients with esophageal squamous cell carcinoma. International Journal of Clinical and Experimental Pathology. ,vol. 7, pp. 7938- 7944 ,(2014)
A Deng, P Luo, Q Chen, J Yin, T Chong, Molecular events are associated with resistance to vinblastine in bladder cancer. Cellular and Molecular Biology. ,vol. 61, pp. 33- 38 ,(2015)
Mark Pickard, Gwyn Williams, Molecular and Cellular Mechanisms of Action of Tumour Suppressor GAS5 LncRNA. Genes. ,vol. 6, pp. 484- 499 ,(2015) , 10.3390/GENES6030484
Feng Wang, Hou-Qun Ying, Bang-Shun He, Yu-Qin Pan, Qi-Wen Deng, Hui-Ling Sun, Jie Chen, Xian Liu, Shu-Kui Wang, Upregulated lncRNA-UCA1 contributes to progression of hepatocellular carcinoma through inhibition of miR-216b and activation of FGFR1/ERK signaling pathway. Oncotarget. ,vol. 6, pp. 7899- 7917 ,(2015) , 10.18632/ONCOTARGET.3219
Mei Xue, Wei Chen, Xu Li, Urothelial cancer associated 1: a long noncoding RNA with a crucial role in cancer Journal of Cancer Research and Clinical Oncology. ,vol. 142, pp. 1407- 1419 ,(2016) , 10.1007/S00432-015-2042-Y
Kentaro Sugano, Screening of gastric cancer in Asia. Best Practice & Research in Clinical Gastroenterology. ,vol. 29, pp. 895- 905 ,(2015) , 10.1016/J.BPG.2015.09.013
Marc C Smaldone, Benjamin J Davies, BC-819, a plasmid comprising the H19 gene regulatory sequences and diphtheria toxin A, for the potential targeted therapy of cancers. Current Opinion in Molecular Therapeutics. ,vol. 12, pp. 607- 616 ,(2010)
James M. Hughes, Ivano Legnini, Beatrice Salvatori, Silvia Masciarelli, Marcella Marchioni, Francesco Fazi, Mariangela Morlando, Irene Bozzoni, Alessandro Fatica, C/EBPα-p30 protein induces expression of the oncogenic long non-coding RNA UCA1 in acute myeloid leukemia Oncotarget. ,vol. 6, pp. 18534- 18544 ,(2015) , 10.18632/ONCOTARGET.4069
Ningning Cheng, Weijing Cai, Shengxiang Ren, Xuefei Li, Qi Wang, Hui Pan, Mingchuan Zhao, Jiayu Li, Yishi Zhang, Chao Zhao, Xiaoxia Chen, Ke Fei, Caicun Zhou, Fred R. Hirsch, Long non-coding RNA UCA1 induces non-T790M acquired resistance to EGFR-TKIs by activating the AKT/mTOR pathway in EGFR -mutant non-small cell lung cancer Oncotarget. ,vol. 6, pp. 23582- 23593 ,(2015) , 10.18632/ONCOTARGET.4361