Molecular events are associated with resistance to vinblastine in bladder cancer.

摘要: Bladder cancer occurs in the majority of cases males, which represents fourth highest incident men and tenth women. It is associated with a high rate recurrence, prognosis poor once metastasizes to distant sites. Transitional cell (TCC) most predominant histological type. highly chemosensitive. However, presence acquired drug resistance one primary impediments success chemotherapy. To differentiate delineate molecular events, we developed resistant human transitional bladder T24 cells (DRC) by treating increasing concentration vinblastine. We found that DRC was vinblastine comparison parental cells. analyzed contributory factors may be involved development resistance. As expected, expression permeability glycoprotein (P-gp) up-regulated DRC. In addition, levels Caveolin-1 (Cav-1), Fatty acid synthase (FASN) Cytochrome P450 (CYP450) were elevated Downregulation these proteins respective specific pharmacological inhibitors and/or siRNAs resensitized These results suggested differential P-gp, Cav-1 FASN except CYP450 play major role phenotype cancer.