S-Palmitoylation as a Functional Regulator of Proteins Associated with Cisplatin Resistance in Bladder Cancer.

摘要: Protein S-palmitoylation is a powerful post-translational modification that regulates protein trafficking, localization, turnover, and signal transduction. Palmitoylation controls several important cellular processes, and, if dysregulated, can lead to cancer, cardiovascular disease, neurological disorders. The role of palmitoylation in mediating resistance systemic cisplatin-based chemotherapies cancer currently unknown. This particular interest because cisplatin the gold standard treatment for bladder (BC), there are no feasible options after acquired. Using unbiased global proteomic profiling purified S-palmitoylated peptides combined with intensive bioinformatics analyses, we identified 506 candidate palmitoylated proteins significantly enriched cisplatin-resistant BC cells. One these included PD-L1, which highly resistant Pharmacological inhibition fatty acid synthase (FASN) suppressed PD-L1 expression, suggests potential use FASN-PD-L1-targeted therapeutic strategies patients. Taken together, results highlight chemoresistance.