Long non-coding RNA UCA1 promotes cisplatin/gemcitabine resistance through CREB modulating miR-196a-5p in bladder cancer cells
作者： Jingjing Pan , Xu Li , Wenjing Wu , Mei Xue , Huilian Hou
DOI: 10.1016/J.CANLET.2016.08.015
关键词:
摘要: Chemoresistance constitutes the major failing of clinical therapy for bladder cancer. However, molecular mechanisms involved in chemoresistance cancer are unclear. Long non-coding RNAs (lncRNAs) have been implicated chemotherapeutic drug resistance. Urothelial Cancer Associated 1 (UCA1), an lncRNA, is reportedly upregulated human carcinoma and promotes cell proliferation, migration, invasion, In present study, knockdown UCA1 decreased chemosensitivity to cisplatin/gemcitabine by suppressing proliferation inducing apoptosis, while overexpression increased cells. Moreover, activated transcription factor CREB which led miR-196a-5p expression binding with its promoter. induction inhibition apoptosis induced via targeting p27Kip1. These results provide a novel UCA1-CREB-miR-196a-5p paradigm explain part how functions resistance, suggest that may be potential therapeutic target chemotherapy
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