Long non-coding RNA UCA1 promotes glycolysis by upregulating hexokinase 2 through the mTOR-STAT3/microRNA143 pathway.
作者： Zhengkun Li , Xu Li , Shouzhen Wu , Mei Xue , Wei Chen
DOI: 10.1111/CAS.12461
关键词: Long non-coding RNA 、 Cell biology 、 PI3K/AKT/mTOR pathway 、 Cancer cell 、 Biochemistry 、 Warburg effect 、 Hexokinase 、 Biology 、 Glycolysis 、 Anaerobic glycolysis 、 microRNA
摘要: Cancer cells preferentially metabolize glucose through aerobic glycolysis, a phenomenon known as the Warburg effect. Emerging evidence has shown that long non-coding RNAs (lncRNAs) act key regulators of multiple cancers. However, it remains largely unexplored whether and how lncRNA regulates metabolism in cancer cells. In this study, we show UCA1 promotes glycolysis bladder cells, UCA1-induced hexokinase 2 (HK2) functions an important mediator process. We further activates mTOR to regulate HK2 both activation STAT3 repression microRNA143. Taken together, these findings provide first plays positive role cell cascade mTOR–STAT3/microRNA143–HK2, reveal novel link between altered
sci-hub.se 参考文章(29)
David P Bartel, MicroRNAs: Genomics, Biogenesis, Mechanism, and Function Cell. ,vol. 116, pp. 281- 297 ,(2004) , 10.1016/S0092-8674(04)00045-5
Q. Sun, X. Chen, J. Ma, H. Peng, F. Wang, X. Zha, Y. Wang, Y. Jing, H. Yang, R. Chen, L. Chang, Y. Zhang, J. Goto, H. Onda, T. Chen, M.-R. Wang, Y. Lu, H. You, D. Kwiatkowski, H. Zhang, Mammalian target of rapamycin up-regulation of pyruvate kinase isoenzyme type M2 is critical for aerobic glycolysis and tumor growth Proceedings of the National Academy of Sciences of the United States of America. ,vol. 108, pp. 4129- 4134 ,(2011) , 10.1073/PNAS.1014769108
Chen Yang, Xu Li, Yu Wang, Le Zhao, Wei Chen, Long non-coding RNA UCA1 regulated cell cycle distribution via CREB through PI3-K dependent pathway in bladder carcinoma cells. Gene. ,vol. 496, pp. 8- 16 ,(2012) , 10.1016/J.GENE.2012.01.012
Alejo Efeyan, David M Sabatini, mTOR and cancer: many loops in one pathway Current Opinion in Cell Biology. ,vol. 22, pp. 169- 176 ,(2010) , 10.1016/J.CEB.2009.10.007
Blake C. Ellis, Lloyd D. Graham, Peter L. Molloy, CRNDE, a long non-coding RNA responsive to insulin/IGF signaling, regulates genes involved in central metabolism. Biochimica et Biophysica Acta. ,vol. 1843, pp. 372- 386 ,(2014) , 10.1016/J.BBAMCR.2013.10.016
Guido Kroemer, Jacques Pouyssegur, Tumor Cell Metabolism: Cancer's Achilles' Heel Cancer Cell. ,vol. 13, pp. 472- 482 ,(2008) , 10.1016/J.CCR.2008.05.005
Steven J. Bensinger, Heather R. Christofk, New aspects of the Warburg effect in cancer cell biology Seminars in Cell & Developmental Biology. ,vol. 23, pp. 352- 361 ,(2012) , 10.1016/J.SEMCDB.2012.02.003
Kiyotaka Yokogami, Shinichiro Wakisaka, Joseph Avruch, Steven A. Reeves, Serine phosphorylation and maximal activation of STAT3 during CNTF signaling is mediated by the rapamycin target mTOR. Current Biology. ,vol. 10, pp. 47- 50 ,(2000) , 10.1016/S0960-9822(99)00268-7
Yu Wang, Wei Chen, Chen Yang, Wenjing Wu, Shouzhen Wu, Xuebin Qin, Xu Li, Long non-coding RNA UCA1a(CUDR) promotes proliferation and tumorigenesis of bladder cancer. International Journal of Oncology. ,vol. 41, pp. 276- 284 ,(2012) , 10.3892/IJO.2012.1443
R B Robey, N Hay, Mitochondrial hexokinases, novel mediators of the antiapoptotic effects of growth factors and Akt Oncogene. ,vol. 25, pp. 4683- 4696 ,(2006) , 10.1038/SJ.ONC.1209595