Urothelial cancer associated 1: a long noncoding RNA with a crucial role in cancer
作者： Mei Xue , Wei Chen , Xu Li
DOI: 10.1007/S00432-015-2042-Y
关键词:
摘要: Urothelial cancer associated 1 (UCA1) is a long noncoding RNA (lncRNA) which has gained more attention in recent years due to its aberrant expression embryogenesis and broad range of tissues cells. Importantly, multiple studies have shown that UCA1 plays oncogenic roles tumor growth metastasis, it may act as potential biomarker therapeutic target for human cancers. However, the molecular mechanism initiation, progression metastasis remains incompletely understood. Thus, gaining better understanding functional onset utmost significance evaluating application UCA1. In this review, we discuss profiling, isoform, regulation, biological role tumor-promoting effect. We further clinical promising diagnostic or functions an lncRNA several malignancies, might become
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