LncRNA-MALAT1 mediates cisplatin resistance via miR-101-3p/VEGF-C pathway in bladder cancer
作者： Peihua Liu , Xiaozhou Li , Yu Cui , Jinbo Chen , Chao Li
DOI: 10.1093/ABBS/GMZ112
关键词:
摘要: Cisplatin (CDDP)-based chemotherapy is a standard strategy for the clinical treatment of patients with bladder cancer (BC). However, anti-tumor efficacy cisplatin affected by multiple chemoresistance complex molecular mechanisms. Recent evidence highlights crucial regulatory roles metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) in progression cancers and development drug resistance. underlying mechanisms MALAT1 resistance BC cells remain largely unclear. In this study, we firstly demonstrated that expression was up-regulated tissues compared to normal adjacent elevated epithelial immortalized cells. Secondly, found suppression enhanced chemotherapeutic sensitivity inhibited Thirdly, showed via regulating miR-101-3p/VEGF-C pathway. summary, study demonstrates MALAT1, miR-101-3p VEGF-C form axis affect chemo-resistance CDDP, provides novel potential targets BC.
oup.com
sci-hub.se 参考文章(41)
David Y Josephson, Erik Pasin, Anirban P Mitra, Richard J Cote, John P Stein, Superficial bladder cancer: an update on etiology, molecular development, classification, and natural history. Reviews in urology. ,vol. 10, pp. 31- 43 ,(2008)
A Deng, P Luo, Q Chen, J Yin, T Chong, Molecular events are associated with resistance to vinblastine in bladder cancer. Cellular and Molecular Biology. ,vol. 61, pp. 33- 38 ,(2015)
ZHENYU LIU, JINGJIE WANG, YUQING MAO, BING ZOU, XIAOMING FAN, MicroRNA-101 suppresses migration and invasion via targeting vascular endothelial growth factor-C in hepatocellular carcinoma cells Oncology Letters. ,vol. 11, pp. 433- 438 ,(2016) , 10.3892/OL.2015.3832
Miao Sun, Shrikanth S. Gadad, Dae-Seok Kim, W. Lee Kraus, Discovery, Annotation, and Functional Analysis of Long Noncoding RNAs Controlling Cell-Cycle Gene Expression and Proliferation in Breast Cancer Cells Molecular Cell. ,vol. 59, pp. 698- 711 ,(2015) , 10.1016/J.MOLCEL.2015.06.023
Rei Yoshimoto, Akila Mayeda, Minoru Yoshida, Shinichi Nakagawa, MALAT1 long non-coding RNA in cancer Biochimica et Biophysica Acta. ,vol. 1859, pp. 192- 199 ,(2016) , 10.1016/J.BBAGRM.2015.09.012
Pedro J. Batista, Howard Y. Chang, Long Noncoding RNAs: Cellular Address Codes in Development and Disease Cell. ,vol. 152, pp. 1298- 1307 ,(2013) , 10.1016/J.CELL.2013.02.012
Mitchell Guttman, John L. Rinn, Modular regulatory principles of large non-coding RNAs Nature. ,vol. 482, pp. 339- 346 ,(2012) , 10.1038/NATURE10887
Sheng Wang, Sheng Xue, Yuanqing Dai, Jianfu Yang, Zhijun Chen, Xiwu Fang, Wensheng Zhou, Wei Wu, Qingwen Li, Reduced expression of microRNA-100 confers unfavorable prognosis in patients with bladder cancer Diagnostic Pathology. ,vol. 7, pp. 159- 159 ,(2012) , 10.1186/1746-1596-7-159
Xuefei Shi, Ming Sun, Hongbing Liu, Yanwen Yao, Yong Song, Long non-coding RNAs: A new frontier in the study of human diseases Cancer Letters. ,vol. 339, pp. 159- 166 ,(2013) , 10.1016/J.CANLET.2013.06.013
L Galluzzi, I Vitale, J Michels, C Brenner, G Szabadkai, A Harel-Bellan, M Castedo, G Kroemer, Systems biology of cisplatin resistance: past, present and future Cell Death and Disease. ,vol. 5, ,(2014) , 10.1038/CDDIS.2013.428