Non-Coding RNAs and Resistance to Anticancer Drugs in Gastrointestinal Tumors.
作者： Jens C. Hahne , Nicola Valeri
关键词: Cancer stem cell 、 Cell cycle 、 Gene expression 、 Drug resistance 、 microRNA 、 Biology 、 Drug metabolism 、 Non-coding RNA 、 Gene 、 Cancer research
摘要: Non-coding RNAs are important regulators of gene expression and transcription. It is well established that impaired non-coding RNA especially the one long microRNAs involved in a number pathological conditions including cancer. responsible for development resistance to anticancer treatments as they regulate drug resistance-related genes, affect intracellular concentrations, induce alternative signalling pathways, alter efficiency via blocking cell cycle regulation DNA damage response. Furthermore, can prevent therapeutic-induced death promote epithelial-mesenchymal transition elicit non-cell autonomous mechanisms resistance. In this review we summarise role different resulting (e.g. transport, metabolism, regulation, apoptotic cancer stem cells transition) context gastrointestinal cancers.
frontiersin.org
sci-hub.se 参考文章(373)
Kevin C. Wang, Yul W. Yang, Bo Liu, Amartya Sanyal, Ryan Corces-Zimmerman, Yong Chen, Bryan R. Lajoie, Angeline Protacio, Ryan A. Flynn, Rajnish A. Gupta, Joanna Wysocka, Ming Lei, Job Dekker, Jill A. Helms, Howard Y. Chang, A long noncoding RNA maintains active chromatin to coordinate homeotic gene expression Nature. ,vol. 472, pp. 120- 124 ,(2011) , 10.1038/NATURE09819
Guangbing Li, Haohai Zhang, Xueshuai Wan, Xiaobo Yang, Chengpei Zhu, Anqiang Wang, Lian He, Ruoyu Miao, Shuguang Chen, Haitao Zhao, Long noncoding RNA plays a key role in metastasis and prognosis of hepatocellular carcinoma. BioMed Research International. ,vol. 2014, pp. 780521- 780521 ,(2014) , 10.1155/2014/780521
Kenji Ikemura, Takuya Iwamoto, Masahiro Okuda, MicroRNAs as regulators of drug transporters, drug-metabolizing enzymes, and tight junctions: implication for intestinal barrier function. Pharmacology & Therapeutics. ,vol. 143, pp. 217- 224 ,(2014) , 10.1016/J.PHARMTHERA.2014.03.002
Yvonne Tay, Jinqiu Zhang, Andrew M. Thomson, Bing Lim, Isidore Rigoutsos, MicroRNAs to Nanog, Oct4 and Sox2 coding regions modulate embryonic stem cell differentiation Nature. ,vol. 455, pp. 1124- 1128 ,(2008) , 10.1038/NATURE07299
Dan Sha, Adam M. Lee, Qian Shi, Steven R. Alberts, Daniel J. Sargent, Frank A. Sinicrope, Robert B. Diasio, Association study of the let-7 miRNA-complementary site variant in the 3' untranslated region of the KRAS gene in stage III colon cancer (NCCTG N0147 clinical trial) Clinical Cancer Research. ,vol. 20, pp. 3319- 3327 ,(2014) , 10.1158/1078-0432.CCR-14-0069
Y Doki, H Ishii, S Hasegawa, H Eguchi, H Nagano, M Konno, Y Tomimaru, H Wada, N Hama, K Kawamoto, S Kobayashi, N Nishida, J Koseki, T Nishimura, N Gotoh, S Ohno, N Yabuta, H Nojima, M Mori, MicroRNA-1246 expression associated with CCNG2-mediated chemoresistance and stemness in pancreatic cancer British Journal of Cancer. ,vol. 111, pp. 1572- 1580 ,(2014) , 10.1038/BJC.2014.454
Imad Matouk, Eli Raveh, Patricia Ohana, Rasha Lail, Eitan Gershtain, Michal Gilon, Nathan De Groot, Abraham Czerniak, Abraham Hochberg, The Increasing Complexity of the Oncofetal H19 Gene Locus: Functional Dissection and Therapeutic Intervention International Journal of Molecular Sciences. ,vol. 14, pp. 4298- 4316 ,(2013) , 10.3390/IJMS14024298
Naohiro Nishida, Shinya Yamashita, Koshi Mimori, Tomoya Sudo, Fumiaki Tanaka, Kohei Shibata, Hirofumi Yamamoto, Hideshi Ishii, Yuichiro Doki, Masaki Mori, MicroRNA-10b is a Prognostic Indicator in Colorectal Cancer and Confers Resistance to the Chemotherapeutic Agent 5-Fluorouracil in Colorectal Cancer Cells Annals of Surgical Oncology. ,vol. 19, pp. 3065- 3071 ,(2012) , 10.1245/S10434-012-2246-1
Ye Zhang, Xiujuan Qu, Ce Li, Yibo Fan, Xiaofang Che, Ximing Wang, Ying Cai, Xuejun Hu, Yunpeng Liu, miR-103/107 modulates multidrug resistance in human gastric carcinoma by downregulating Cav-1 Tumor Biology. ,vol. 36, pp. 2277- 2285 ,(2015) , 10.1007/S13277-014-2835-7
Ivan Ischenko, Hendrik Seeliger, Axel Kleespies, Martin K. Angele, Martin E. Eichhorn, Karl-Walter Jauch, Christiane J. Bruns, Pancreatic cancer stem cells: new understanding of tumorigenesis, clinical implications. Langenbeck's Archives of Surgery. ,vol. 395, pp. 1- 10 ,(2010) , 10.1007/S00423-009-0502-Z