miR-103/107 modulates multidrug resistance in human gastric carcinoma by downregulating Cav-1
作者： Ye Zhang , Xiujuan Qu , Ce Li , Yibo Fan , Xiaofang Che
DOI: 10.1007/S13277-014-2835-7
关键词:
摘要: MicroRNAs (miRNAs) are a class of non-protein-coding small RNAs with the capacity to regulate fundamental biological processes essential for cancer initiation and progression. In present study, we analyzed miRNA expression levels between multidrug-resistant gastric carcinoma cell line SGC7901/ADR its parent SGC7901 using microarray. MiR-103/107 was downregulated compared parental cells. Overexpression miR-103/107 sensitized cells doxorubicin (DOX), as demonstrated by in vitro vivo drug sensitivity assay. We further confirmed that inhibited P-gp function Finally, verified caveolin-1 (Cav-1), critical component lipid rafts, target miR-103/107.
springer.com
sci-hub.se 参考文章(32)
David P Bartel, MicroRNAs: Genomics, Biogenesis, Mechanism, and Function Cell. ,vol. 116, pp. 281- 297 ,(2004) , 10.1016/S0092-8674(04)00045-5
Hyung Gyun Kim, Tran Thi Hien, Eun Hee Han, Yong Pil Hwang, Jae Ho Choi, Keon Wook Kang, Kwang-il Kwon, Bong-Hee Kim, Sang Kyum Kim, Gye Yong Song, Tae Cheon Jeong, Hye Gwang Jeong, Metformin inhibits P-glycoprotein expression via the NF-κB pathway and CRE transcriptional activity through AMPK activation. British Journal of Pharmacology. ,vol. 162, pp. 1096- 1108 ,(2011) , 10.1111/J.1476-5381.2010.01101.X
Ke Xu, Xin Liang, Daling Cui, Yixin Wu, Weibin Shi, Jianwen Liu, miR-1915 inhibits Bcl-2 to modulate multidrug resistance by increasing drug-sensitivity in human colorectal carcinoma cells. Molecular Carcinogenesis. ,vol. 52, pp. 70- 78 ,(2013) , 10.1002/MC.21832
Junqing Chen, Wei Tian, Hongke Cai, Haifei He, Yongchuan Deng, Down-regulation of microRNA-200c is associated with drug resistance in human breast cancer Medical Oncology. ,vol. 29, pp. 2527- 2534 ,(2012) , 10.1007/S12032-011-0117-4
A. Cervantes, D. Roda, N. Tarazona, S. Roselló, J.A. Pérez-Fidalgo, Current questions for the treatment of advanced gastric cancer. Cancer Treatment Reviews. ,vol. 39, pp. 60- 67 ,(2013) , 10.1016/J.CTRV.2012.09.007
S. Orlowski, S. Martin, A. Escargueil, P-glycoprotein and 'lipid rafts': some ambiguous mutual relationships (floating on them, building them or meeting them by chance?). Cellular and Molecular Life Sciences. ,vol. 63, pp. 1038- 1059 ,(2006) , 10.1007/S00018-005-5554-9
P. Ru, R. Steele, E. C. Hsueh, R. B. Ray, Anti-miR-203 Upregulates SOCS3 Expression in Breast Cancer Cells and Enhances Cisplatin Chemosensitivity Genes & Cancer. ,vol. 2, pp. 720- 727 ,(2011) , 10.1177/1947601911425832
Kristen M. Pluchino, Matthew D. Hall, Andrew S. Goldsborough, Richard Callaghan, Michael M. Gottesman, Collateral sensitivity as a strategy against cancer multidrug resistance. Drug Resistance Updates. ,vol. 15, pp. 98- 105 ,(2012) , 10.1016/J.DRUP.2012.03.002
Szabolcs Modok, Catherine Heyward, Richard Callaghan, P-glycoprotein retains function when reconstituted into a sphingolipid- and cholesterol-rich environment Journal of Lipid Research. ,vol. 45, pp. 1910- 1918 ,(2004) , 10.1194/JLR.M400220-JLR200
Avtar Singh Meena, Aanchal Sharma, Ratna Kumari, Naoshad Mohammad, Shivendra Vikram Singh, Manoj Kumar Bhat, None, Inherent and acquired resistance to paclitaxel in hepatocellular carcinoma: molecular events involved. PLOS ONE. ,vol. 8, ,(2013) , 10.1371/JOURNAL.PONE.0061524