Epigenetic modulation as a therapeutic approach for pulmonary arterial hypertension
作者： Jun-Dae Kim , Aram Lee , Jihea Choi , Youngsook Park , Hyesoo Kang
DOI: 10.1038/EMM.2015.45
关键词:
摘要: Pulmonary arterial hypertension (PAH) is a rare but progressive and currently incurable disease, which characterized by vascular remodeling in association with muscularization of the arterioles, medial thickening plexiform lesion formation. Despite our advanced understanding pathogenesis PAH recent therapeutic advances, still remains fatal disease. In addition, susceptibility to has not yet been adequately explained. Much evidence points involvement epigenetic changes number human diseases including cancer, peripheral asthma. The knowledge gained from study various can also be applied PAH. Thus, pursuit novel targets via alterations involved PAH, such as DNA methylation, histone modification microRNA, might an attractive avenue for development more effective treatment. This review provides general overview current advances epigenetics associated discusses potential improved treatment through role
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