The Increasing Complexity of the Oncofetal H19 Gene Locus: Functional Dissection and Therapeutic Intervention

摘要: The field of the long non-coding RNA (lncRNA) is advancing rapidly. Currently, it one most popular fields in biological and medical sciences. It becoming increasingly obvious that majority human transcriptome has little or no-protein coding capacity. Historically, H19 was first imprinted (ncRNA) transcript identified, H19/IGF2 locus served as a paradigm for study genomic imprinting since its discovery. In recent years, we have extensively investigated expression gene number cancers explored role tumor development. Here, discuss recently published data from our group others provide further support central process tumorigenesis. Furthermore, focus on major transcriptional modulators them context tumor-promoting activity RNA. Based pivotal cancers, developed DNA-based therapeutic approach treatment upregulated levels expression. This uses diphtheria toxin A (DTA) protein expressed under regulation promoter to treat tumors with significant this review, four cancer indications subjects using approach, which currently represents perhaps very few examples an existing therapy centered lncRNA system. Apart cancer, been reported also other conditions, syndromes diseases, where deregulated at some cases will be summarized below. Moreover, proved much more complicated than initially thought. houses sequence can transcribe, yielding various outputs, both sense antisense directions. outputs are presented here.