Thrombin signalling and protease-activated receptors
作者： Shaun R. Coughlin
DOI: 10.1038/35025229
关键词: Signal transduction 、 Coagulation factor II receptor 、 Cell biology 、 Coagulation 、 Protease-activated receptor 、 Endocrinology 、 Biology 、 Thrombin 、 Protease 、 Platelet activation 、 Receptor 、 Internal medicine
摘要: How does the coagulation protease thrombin regulate cellular behaviour? The protease-activated receptors (PARs) provide one answer. In concert with cascade, these an elegant mechanism linking mechanical information in form of tissue injury or vascular leakage to responses. Roles for PARs are beginning emerge haemostasis and thrombosis, inflammation, perhaps even blood vessel development.
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