Proton Beam Therapy for Bronchogenic Adenoid Cystic Carcinoma: Dosimetry, Toxicities, and Outcomes

摘要: Abstract Purpose: Bronchogenicadenoid cystic carcinoma (ACC) is a rare malignancy particularly challenging to irradiate, largely owing anatomic location and associated toxicities. Proton beam therapy (PBT) can reduce doses nearby organs at risk, but only one case report has been published detailing PBT for this neoplasm. Patients Methods: This study was an institutional review board–approved retrospective chart of all patients institution with bronchogenic ACC treated PBT. Toxicities were assessed per Common Toxicity Criteria Adverse Events, version 4.0. Results: Five patients, median age 67 years (range = 40-97 years), symptomatic before Two debulked PBT, which delivered 66.6 Gy (RBE) (range, 57.5-80 (RBE)). received concurrent platinum-based chemotherapy. Symptoms improved in patients. Acute toxicities included the following: grade 1 fatigue (n = 3), dermatitis (n = 2), esophagitis (n ...