Synthesis of 10‐deazapteroic and 11‐deazahomopteroic acids
作者： Joseph I. Degraw , Panayotis Tsakotellis , Roy L. Kisliuk , Yvette Gaumont
关键词: Antimalarial Agent 、 Pteridine 、 Plasmodium gallinaceum 、 Plasmodium berghei 、 Stereochemistry 、 Biochemistry 、 Chemistry 、 Streptococcus
摘要: The syntheses of 10-deazapteroic and 11-deazahomopteroic acids are described. These compounds along with their simple 6-phenylalkylpteridinol relatives were found to be inactive as antimalarial agents against the Plasmodium berghei or gallinaceum strains. 10-Deazapteroie acid was a potent growth inhibitor Streptococcus faecium both in pteridine tetrahydropteridine forms.
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