A model with combined viral and metabolic factors effectively predicts HBeAg status under long term entecavir therapy: a prospective cohort study
作者： Fen Liu , Feng Zou , Xiwei Wang , Huaidong Hu , Peng Hu
DOI: 10.1186/S12985-015-0409-Y
关键词: Body mass index 、 Alanine transaminase 、 Prospective cohort study 、 Serology 、 Entecavir 、 Medicine 、 Young adult 、 Seroconversion 、 Virology 、 HBeAg
摘要: The aim was to extract factors from virologic and biochemical profiles at baseline 24 weeks of treatment predict HBeAg seroconversion in patients treated with ETV. positive chronic hepatitis B receiving ETV naive-treatment were enrolled. HBV DNA, ALT, serological markers prospectively monitored every 6 months for 240 weeks. cumulative rates response (VR), (BR), determined, potential predictors identified through uni/multivariate analysis. Two hundred twenty nine eligible this study. VR, BR, 88.4 %, 100 36.7 respectively. Multivariate analysis showed that DNA (OR, 2.8, p = 0.003), ALT 2.6, 0.005) baseline, undetectable within (OR 3.2, 40 %), intermediate (20–40 or low (≤20 %) groups based on the calculated probability seroconversion. different among three (p < 0.001). About 58 % high group achieved while almost 90 remained positive. A combination BMI values level can Both viral metabolic likely determine status treatment. CTR20132358
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