A one-year trial of entecavir treatment in patients with HBeAg-positive chronic hepatitis B.
作者： Fen-Yu Ren
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摘要: AIM: To evaluate the efficacy and safety of entecavir (ETV) in hepatitis Be antigen (HBeAg)-positive chronic B (CHB) patients who had not received a nucleoside analogue failed lamivudine (LVD) therapy. METHODS: Sixty-one were divided into three groups. Forty-two randomized two groups: group A (n = 21) LVD 100 mg/d ETV 0.5 mg/d. The remaing 19 treated with 19), switched to 1.0 served as C. All for 48 wk. HBV DNA levels measured polimerase-chain-reaction (PCR) analysis. Liver function tests, serology assessments also conducted. RESULTS: Significantly more (52.1% 71.4%) undetectable than groups (35.8% 38%; P < 0.0001) C (10.6% 21.1%, at week 24 48, respectively. At wk ALT normalized (85.7%) (76.2%) (74%). CONCLUSION: significantly higher response rate HBeAg-positive CHB previously analogue; can effectively inhibit replication normalize refractory LVD; is safe clinical application.
sci-hub.st 参考文章(19)
Ching-Lung Lai, Rong-Nan Chien, Nancy W.Y. Leung, Ting-Tsung Chang, Richard Guan, Dar-In Tai, Keng-Yeen Ng, Pui-Chee Wu, Julie C. Dent, Judy Barber, Sally L. Stephenson, D. Fraser Gray, A One-Year Trial of Lamivudine for Chronic Hepatitis B The New England Journal of Medicine. ,vol. 339, pp. 61- 68 ,(1998) , 10.1056/NEJM199807093390201
Patrick Marcellin, Ting-Tsung Chang, Seng Gee Lim, Myron J Tong, William Sievert, Mitchell L Shiffman, Lennox Jeffers, Zachary Goodman, Michael S Wulfsohn, Shelly Xiong, John Fry, Carol L Brosgart, None, Adefovir dipivoxil for the treatment of hepatitis B e antigen-positive chronic hepatitis B. The New England Journal of Medicine. ,vol. 348, pp. 808- 816 ,(2003) , 10.1056/NEJMOA020681
Yun-Fan Liaw, Impact of YMDD mutations during lamivudine therapy in patients with chronic hepatitis B. Antiviral Chemistry & Chemotherapy. ,vol. 12, pp. 67- 71 ,(2001)
Chang TingTsung Chang TingTsung, RG Gish, R de Man, A Gadano, J Sollano, Chao YouChen Chao YouChen, AS Lok, Han KwangHyub Han KwangHyub, Z Goodman, J Zhu, A Cross, D DeHertogh, R Wilber, R Colonno, D Apelian, A comparison of entecavir and lamivudine for HBeAg-positive chronic hepatitis B The New England Journal of Medicine. ,vol. 354, pp. 1001- 1010 ,(2006) , 10.1056/NEJMOA051285
Yun-Fan Liaw, Rong-Nan Chien, Chau-Ting Yeh, Sun-Lung Tsai, Chia-Ming Chu, Acute exacerbation and hepatitis B virus clearance after emergence of YMDD motif mutation during lamivudine therapy Hepatology. ,vol. 30, pp. 567- 572 ,(1999) , 10.1002/HEP.510300221
Yun-Fan Liaw, Joseph JY Sung, Wan Cheng Chow, Geoffrey Farrell, Cha-Ze Lee, Hon Yuen, Tawesak Tanwandee, Qi-Min Tao, Kelly Shue, Oliver N Keene, Jonathan S Dixon, D Fraser Gray, Jan Sabbat, None, Lamivudine for Patients with Chronic Hepatitis B and Advanced Liver Disease The New England Journal of Medicine. ,vol. 351, pp. 1521- 1531 ,(2004) , 10.1056/NEJMOA033364
Ting–Tsung Chang, Robert G Gish, Stephanos J Hadziyannis, Janusz Cianciara, Mario Rizzetto, Eugene R Schiff, Giuseppe Pastore, Bruce R Bacon, Thierry Poynard, Shobha Joshi, Kenneth S Klesczewski, Alexandra Thiry, Ronald E Rose, Richard J Colonno, Robert G Hindes, BEHoLD Study Group, A Dose-Ranging Study of the Efficacy and Tolerability of Entecavir in Lamivudine-refractory Chronic Hepatitis B Patients Gastroenterology. ,vol. 129, pp. 1198- 1209 ,(2005) , 10.1053/J.GASTRO.2005.06.055
Yun–Fan Liaw, Nancy WY Leung, Ting–Tsung Chang, Richard Guan, Dar–In Tai, Keng–Yeen Ng, Rong–Nan Chien, Julie Dent, Lise Roman, Sally Edmundson, Ching–Lung Lai, Asia Hepatitis Lamivudine Study Group, None, Effects of extended lamivudine therapy in Asian patients with chronic hepatitis B Gastroenterology. ,vol. 119, pp. 172- 180 ,(2000) , 10.1053/GAST.2000.8559
Stephanos J. Hadziyannis, Nicolaos C. Tassopoulos, E. Jenny Heathcote, Ting-Tsung Chang, George Kitis, Mario Rizzetto, Patrick Marcellin, Seng Gee Lim, Zachary Goodman, Jia Ma, Sarah Arterburn, Shelly Xiong, Graeme Currie, Carol L. Brosgart, Long-term therapy with adefovir dipivoxil for HBeAg-negative chronic hepatitis B The New England Journal of Medicine. ,vol. 352, pp. 2673- 2681 ,(2005) , 10.1056/NEJMOA042957
TING-TSUNG CHANG, CHING-LUNG LAI, RONG-NAN CHIEN, RICHARD GUAN, SENG-GEE LIM, CHUAN-MO LEE, KENG-YEEN NG, GRAHAM J NICHOLLS, JULIE C DENT, NANCY WY LEUNG, Four years of lamivudine treatment in Chinese patients with chronic hepatitis B. Journal of Gastroenterology and Hepatology. ,vol. 19, pp. 1276- 1282 ,(2004) , 10.1111/J.1440-1746.2004.03428.X