Mixed Treatment Comparison Meta-Analysis Evaluating the Relative Efficacy of Nucleos(t)ides for Treatment of Nucleos(t)ide-Naive Patients with Chronic Hepatitis B

作者: Helen Dakin , Carrie Fidler , Christie Harper

DOI: 10.1111/J.1524-4733.2010.00777.X

关键词: Viral hepatitisHepatitis BMedicineHepatitis B virusImmunologyHBeAgTelbivudineAdefovirLamivudineEntecavirInternal medicineGastroenterology

摘要: Abstract Background/aims Five nucleoside/nucleotide treatments are now available for chronic hepatitis B (CHB). This meta-analysis aimed to assess the relative efficacy of adefovir, entecavir, lamivudine, telbivudine, tenofovir disoproxil fumarate (TDF), and nucleos(t)ide combinations in treatment CHB. Methods A systematic review MEDLINE Cochrane library was conducted identify all studies evaluating these nucleos(t)ides adults with Randomized controlled trials were included if they reported proportion patients undetectable virus (HBV) DNA or e antigen (HBeAg) loss/seroconversion at 1 year. Bayesian mixed comparison meta-analyses WinBUGS efficacy. Results random-effects on treatment-naive HBeAg-positive CHB demonstrated that 94% will achieve HBV Conclusions In nucleos(t)ide-naive CHB, TDF is associated highest probability achieving year considered.

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