Cardiac risk and schizophrenia.

摘要: Sudden cardiac death, which is defined as death from a cause within short time (minutes to hours) after symptoms initially appear, often without warning, major public health problem, accounting for about 10% of all natural deaths and over 50% coronary mortality. Most individuals who die sudden have no history heart disease. 1 Patients with schizophrenia been reported be 3 times likely experience unexpected than the general population, 2 although specific aspects contributing this increased risk remain unclear. Different factors related underlying pathology, antipsychotic medications lifestyle (e.g., smoking, neglect health, poor diet decreased access care services) may contribute mortality in these patients. A recent study found that patients received medication were 1.4 more unexpectedly drug free. However, did not include taking any atypical (secondgeneration) drugs. Cases subjects drugs, but review drugs indicates they are generally safe. 4 The situation regard confounded by fact there an excess even when treated number other co-administered also associated QTc prolongation, 5 discussed below. measures shown predict arrhythmias non-diseased observed schizophrenia. For example, prolonged QT interval (increased taken recover previous contraction) or (QT corrected rate) has factor such events,