Altered diurnal autonomic variation and reduced vagal information flow in acute schizophrenia.
作者： S BOETTGER , D HOYER , K FALKENHAHN , M KAATZ , V YERAGANI
DOI: 10.1016/J.CLINPH.2006.08.009
关键词:
摘要: Abstract Objective This study aimed to further investigate autonomic function in schizophrenic patients using long-term electrocardiographic (ECG) recordings. Methods Twenty unmedicated suffering from an acute episode of paranoid schizophrenia and 20 matched control subjects were recruited 24-h ambulatory electrocardiograms recorded. In order complexity heart rate fluctuations related different physiological time scales, linear variability (HRV) as well information flow (AIF) parameters calculated day night intervals. Results While rates increased, root mean successive square difference (RMSSD), a measure for vagal standard deviation 5-min NN-intervals (SDANN), reflecting parasympathetic sympathetic tone, decreased schizophrenia. Furthermore, decrease was apparent during (decreased high frequency peak decay (PD mHF )). addition, increased INT NN (area under the AIF curve) beat (BD ) very low PD mVLF indicated reduced time. Conclusions HRV indicate altered diurnal variation Significance Reduced modulation loss might both contribute risk sudden cardiac death
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