Apoptosis of murine thymocytes induced by extracellular ATP is dose- and cytosolic pH-dependent

作者: Péter V Nagy , Tamás Fehér , Sabina Morga , János Matkó

DOI: 10.1016/S0165-2478(00)00168-1

关键词: ExtracellularChannel blockerApoptosisPurinergic receptorMembrane potentialDepolarizationHyperpolarization (biology)DNA fragmentationMolecular biologyBiology

摘要: … P2z (P2x7) lytic purinoreceptors have been identified and characterized in … ATP-induced responses suggests that ATP ec may act as a potential regulator of different cell death …

参考文章(32)
C Uneyama, H Uneyama, M Takahashi, N Akaike, Cytoplasmic pH regulates ATP-induced Ca2+-dependent K+-current oscillation in rat megakaryocytes Biochemical Journal. ,vol. 295, pp. 317- 320 ,(1993) , 10.1042/BJ2950317
Jason E. Reynolds, Alan Eastman, Michael A. Barry, Etoposide-induced Apoptosis in Human HL-60 Cells Is Associated with Intracellular Acidification Cancer Research. ,vol. 53, pp. 2349- 2357 ,(1993)
R K Cheung, S Grinstein, E W Gelfand, Calcium-dependent intracellular acidification dominates the pH response to mitogen in human T cells. Journal of Immunology. ,vol. 140, pp. 246- 252 ,(1988)
S G Apasov, T M Chused, M V Sitkovsky, M Koshiba, Effects of extracellular ATP and adenosine on different thymocyte subsets: possible role of ATP-gated channels and G protein-coupled purinergic receptor. Journal of Immunology. ,vol. 158, pp. 5095- 5105 ,(1997)
S Apasov, T M Chused, M Sitkovsky, Murine T lymphocytes modulate activity of an ATP-activated P2Z-type purinoceptor during differentiation. Journal of Immunology. ,vol. 157, pp. 1371- 1380 ,(1996)
M. Murgia, S. Hanau, P. Pizzo, M. Rippa, F. Di Virgilio, Oxidized ATP. An irreversible inhibitor of the macrophage purinergic P2Z receptor. Journal of Biological Chemistry. ,vol. 268, pp. 8199- 8203 ,(1993) , 10.1016/S0021-9258(18)53082-9
G Buell, R J Evans, A Surprenant, R A North, C Lewis, S Valera, Pharmacological characterization of heterologously expressed ATP-gated cation channels (P2x purinoceptors). Molecular Pharmacology. ,vol. 48, pp. 178- 183 ,(1995)
Daisuke SHIOKAWA, Sei-ichi TANUMA, Molecular cloning and expression of a cDNA encoding an apoptotic endonuclease DNase gamma. Biochemical Journal. ,vol. 332, pp. 713- 720 ,(1998) , 10.1042/BJ3320713