Spectrum effects of a new polypeptide (third hormone?) isolated from the chicken pancreas

摘要: Abstract A broad evaluation was made of the biological effects a new polypeptide (APP), 36 amino acid residues, MW 4200, isolated from chicken pancreas. APP is an effective hepatic glycogenolytic and plasma hypoglycerolemic agent in absence glucose perturbation. (at much lower doses) also powerful gastric secretogogue, inducing within seconds marked increases proventricular volume, H + , pepsin, total protein release. Such response not mediated through systemic cardiovascular alterations or vagus nerves, are quite opposite to those observed with beef glucagon. It concluded that pancreas releases exert “gastrinlike” secretogogic action on proventriculus and, at higher concentrations, metabolic as well.