Predictive markers in primary breast cancer compared with lymph node and bloodspread metastases

摘要: High levels of HER2 expression identify those patients who might benefit from treatments that target HER2. Among women with metastatic breast cancer, the predictive markers may be different primary tumor. We compared markers: Estrogen Receptor (ER), Progesterone (PR) and carcinomas lymph node (LN) blood spread metastases (BM). ER, PR status were between tumor LN metastasis metastasis. performed on core biopsies available FNA cell blocks lesions using FDA approved antibodies HercepTest (Dako). ER positive when >/=10%. Her2 was (amplified/expressed) 3+ >30% by immunostain or >2.2 FISH. Sixty four cancer included in this analysis. Forty-eight had (35 [73 %] diagnosed FNA) twenty seven BM (16 [60 FNA). P value determined comparing for p values 0.45 0.57 respectively, 0.31 0.06 0.07. All three are similar two sites (lymph node, bloodspread). Only versus is there a tendency (P 0.06, 0.07) to different. For HER2, majority (FNA), fixed ethanol rather than formalin, which have caused false expression.