ErbB-2 is a common auxiliary subunit of NDF and EGF receptors: implications for breast cancer

作者: D. Karunagaran , E. Tzahar , R. R. Beerli , X. Chen , D. Graus-Porta

DOI: 10.1002/J.1460-2075.1996.TB00356.X

关键词:

摘要: Overexpression of the erbB‐2 gene contributes to aggressive behavior of various human adenocarcinomas, including breast cancer, through an unknown molecular mechanism. The …

参考文章(57)
Brammar Wj, Walker Ra, Varley Jm, Whittaker Jl, Swallow Je, Alterations to either c-erbB-2(neu) or c-myc proto-oncogenes in breast carcinomas correlate with poor short-term prognosis. Oncogene. ,vol. 1, pp. 423- 430 ,(1987)
E. Peles, R.B. Levy, E. Or, A. Ullrich, Y. Yarden, Oncogenic forms of the neu/HER2 tyrosine kinase are permanently coupled to phospholipase C gamma. The EMBO Journal. ,vol. 10, pp. 2077- 2086 ,(1991) , 10.1002/J.1460-2075.1991.TB07739.X
S.S. Huang, J.S. Huang, Purification and characterization of the neu/erb B2 ligand-growth factor from bovine kidney. Journal of Biological Chemistry. ,vol. 267, pp. 11508- 11512 ,(1992) , 10.1016/S0021-9258(19)49939-0
K.L. Carraway, M.X. Sliwkowski, R. Akita, J.V. Platko, P.M. Guy, A. Nuijens, A.J. Diamonti, R.L. Vandlen, L.C. Cantley, R.A. Cerione, The erbB3 gene product is a receptor for heregulin. Journal of Biological Chemistry. ,vol. 269, pp. 14303- 14306 ,(1994) , 10.1016/S0021-9258(17)36789-3
R.R. Beerli, W. Wels, N.E. Hynes, Intracellular expression of single chain antibodies reverts ErbB-2 transformation Journal of Biological Chemistry. ,vol. 269, pp. 23931- 23936 ,(1994) , 10.1016/S0021-9258(19)51027-4
K. Tobe, T. Kadowaki, H. Tamemoto, K. Ueki, K. Hara, O. Koshio, K. Momomura, Y. Gotoh, E. Nishida, Y. Akanuma, Insulin and 12-O-tetradecanoylphorbol-13-acetate activation of two immunologically distinct myelin basic protein/microtubule-associated protein 2 (MBP/MAP2) kinases via de novo phosphorylation of threonine and tyrosine residues. Journal of Biological Chemistry. ,vol. 266, pp. 24793- 24803 ,(1991) , 10.1016/S0021-9258(18)54299-X
D Karunagaran, G Levkowitz, E Tzahar, A Yayon, S Lavi, N Liu, D Wen, E Peles, L Yi, D Chang, ErbB-3 and ErbB-4 function as the respective low and high affinity receptors of all Neu differentiation factor/heregulin isoforms. Journal of Biological Chemistry. ,vol. 269, pp. 25226- 25233 ,(1994) , 10.1016/S0021-9258(17)31521-1