Alternative Use of Signaling by the βGBP Cytokine in Cell Growth and Cancer Control

摘要: βGBP is an antiproliferative cytokine produced by activated T-cells and endogenously released somatic cells. In normal cells, negatively regulates the cell cycle; in cancer cells induces apoptosis. Mechanisms of action involve downregulation PI3 kinase via p110 targeting. Downregulation reflects on Ras-ERK signaling Akt mediated resulting delay S/G2 transition activation programmed death The apoptotic response to takes place according molecular context Where cell-cycle arrest, apoptosis relates E2F-1 deregulation. characterized strong mitogenic input elevated Akt/PKB expression, loss protein deprives survival signaling. immunomolecule which can perform therapeutically what native, endogenous would naturally a surveillance role.