Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics.
作者： Anthony Letai , Michael C. Bassik , Loren D. Walensky , Mia D. Sorcinelli , Solly Weiler
DOI: 10.1016/S1535-6108(02)00127-7
关键词: Cell biology 、 Bcl-2-associated X protein 、 Bcl-2 Homologous Antagonist-Killer Protein 、 Jurkat cells 、 BH3 Mimetic ABT-737 、 Membrane protein 、 Cytochrome c 、 Biology 、 Mitochondrion 、 Bcl-2 family
摘要: The “BH3-only” proteins of the BCL-2 family require “multidomain” proapoptotic members BAX and BAK to release cytochrome c from mitochondria and kill cells. We find short peptides …
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