Tumor necrosis factor (TNF)-mediated kinase cascades: Bifurcation of Nuclear Factor-κB and c-jun N-terminal kinase (JNK/SAPK) pathways at TNF receptor-associated factor 2
作者： H. Y. Song , C. H. Regnier , C. J. Kirschning , D. V. Goeddel , M. Rothe
关键词: MAP kinase kinase kinase 、 Chemistry 、 Kinase 、 TRAF2 、 Cancer research 、 Tumor Necrosis Factor Receptor-Associated Factors 、 Signal transduction 、 TNF receptor associated factor 、 NFKB1 、 c-jun
摘要: TNF-induced activation of the transcription factor NF-κB and c-jun N-terminal kinase (JNK/SAPK) requires TNF receptor-associated 2 (TRAF2). The NF-κB-inducing (NIK) associates with TRAF2 mediates NF-κB. Herein we show that NIK interacts additional members TRAF family this interaction conserved “WKI” motif within domain. We also investigated role in JNK by TNF. Whereas overexpression potently induced activation, it failed to stimulate activation. A kinase-inactive mutant was a dominant negative inhibitor but did not suppress TNF- or TRAF2-induced Thus, is bifurcation point two cascades leading JNK, respectively.
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sci-hub.se 参考文章(43)
Hiroyasu Nakano, Hideo Oshima, Winston Chung, Laura Williams-Abbott, Carl F. Ware, Hideo Yagita, Ko Okumura, TRAF5, an Activator of NF-κB and Putative Signal Transducer for the Lymphotoxin-β Receptor Journal of Biological Chemistry. ,vol. 271, pp. 14661- 14664 ,(1996) , 10.1074/JBC.271.25.14661
M. Rothe, V. Sarma, V. Dixit, D. Goeddel, TRAF2-mediated activation of NF-kappa B by TNF receptor 2 and CD40 Science. ,vol. 269, pp. 1424- 1427 ,(1995) , 10.1126/SCIENCE.7544915
Mike Rothe, Suzy C. Wong, William J. Henzel, David V. Goeddel, A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptor Cell. ,vol. 78, pp. 681- 692 ,(1994) , 10.1016/0092-8674(94)90532-0
Masahiro Takeuchi, Mike Rothe, David V. Goeddel, Anatomy of TRAF2 Journal of Biological Chemistry. ,vol. 271, pp. 19935- 19942 ,(1996) , 10.1074/JBC.271.33.19935
Richard W. Gedrich, Molly C. Gilfillan, Colin S. Duckett, Jennifer L. Van Dongen, Craig B. Thompson, CD30 contains two binding sites with different specificities for members of the tumor necrosis factor receptor-associated factor family of signal transducing proteins Journal of Biological Chemistry. ,vol. 271, pp. 12852- 12858 ,(1996) , 10.1074/JBC.271.22.12852
Mike Rothe, Ming-Gui Pan, William J. Henzel, T.Merrill Ayres, David V. Goeddel, The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins Cell. ,vol. 83, pp. 1243- 1252 ,(1995) , 10.1016/0092-8674(95)90149-3
A Minden, A Lin, M McMahon, C Lange-Carter, B Derijard, R. Davis, G. Johnson, M Karin, Differential Activation of ERK and JNK Mitogen-Activated Protein Kinases by Raf-1 and MEKK Science. ,vol. 266, pp. 1719- 1723 ,(1994) , 10.1126/SCIENCE.7992057
Scot A. Marsters, T. Merrill Ayres, Maya Skubatch, Christa L. Gray, Mike Rothe, Avi Ashkenazi, Herpesvirus Entry Mediator, a Member of the Tumor Necrosis Factor Receptor (TNFR) Family, Interacts with Members of the TNFR-associated Factor Family and Activates the Transcription Factors NF-κB and AP-1 Journal of Biological Chemistry. ,vol. 272, pp. 14029- 14032 ,(1997) , 10.1074/JBC.272.22.14029
M. Rothe, J. Xiong, H. B. Shu, K. Williamson, A. Goddard, D. V. Goeddel, I-TRAF is a novel TRAF-interacting protein that regulates TRAF-mediated signal transduction Proceedings of the National Academy of Sciences of the United States of America. ,vol. 93, pp. 8241- 8246 ,(1996) , 10.1073/PNAS.93.16.8241
Hailing Hsu, Irina Solovyev, Anne Colombero, Robin Elliott, Michael Kelley, William J. Boyle, ATAR, a novel tumor necrosis factor receptor family member, signals through TRAF2 and TRAF5. Journal of Biological Chemistry. ,vol. 272, pp. 13471- 13474 ,(1997) , 10.1074/JBC.272.21.13471