TRAF2-mediated activation of NF-kappa B by TNF receptor 2 and CD40
作者： M. Rothe , V. Sarma , V. Dixit , D. Goeddel
关键词:
摘要: TNF receptor-associated factor (TRAF) proteins are candidate signal transducers that associate with the cytoplasmic domains of members tumor necrosis (TNF) receptor superfamily. The role TRAFs in TNF-R2 and CD40 transduction pathways, which result activation transcription NF-kappa B, was investigated. Overexpression TRAF2, but not TRAF1 or TRAF3, sufficient to induce B activation. A truncated derivative TRAF2 lacking an amino-terminal RING finger domain a dominant-negative inhibitor mediated by CD40. Thus, is common mediator signaling.
sciencemag.org
harvard.edu参考文章(21)
D Pennica, V.T. Lam, N.K. Mize, R.F. Weber, M Lewis, B.M. Fendly, M.T. Lipari, D.V. Goeddel, Biochemical properties of the 75-kDa tumor necrosis factor receptor. Characterization of ligand binding, internalization, and receptor phosphorylation. Journal of Biological Chemistry. ,vol. 267, pp. 21172- 21178 ,(1992) , 10.1016/S0021-9258(19)36813-9
A. Laegreid, A. Medvedev, U. Nonstad, M.P. Bombara, G. Ranges, A. Sundan, T. Espevik, Tumor necrosis factor receptor p75 mediates cell-specific activation of nuclear factor kappa B and induction of human cytomegalovirus enhancer. Journal of Biological Chemistry. ,vol. 269, pp. 7785- 7791 ,(1994) , 10.1016/S0021-9258(17)37355-6
K Wiegmann, S Schütze, E Kampen, A Himmler, T Machleidt, M Krönke, Human 55-kDa receptor for tumor necrosis factor coupled to signal transduction cascades. Journal of Biological Chemistry. ,vol. 267, pp. 17997- 18001 ,(1992) , 10.1016/S0021-9258(19)37142-X
E A Clark, G L Shu, I Berberich, Cross-linking CD40 on B cells rapidly activates nuclear factor-kappa B. Journal of Immunology. ,vol. 153, pp. 4357- 4366 ,(1994)
Mike Rothe, Suzy C. Wong, William J. Henzel, David V. Goeddel, A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptor Cell. ,vol. 78, pp. 681- 692 ,(1994) , 10.1016/0092-8674(94)90532-0
Dimitris Thanos, Tom Maniatis, NF-κB: A lesson in family values Cell. ,vol. 80, pp. 529- 532 ,(1995) , 10.1016/0092-8674(95)90506-5
Craig A. Smith, Terry Farrah, Raymond G. Goodwin, The TNF receptor superfamily of cellular and viral proteins: Activation, costimulation, and death Cell. ,vol. 76, pp. 959- 962 ,(1994) , 10.1016/0092-8674(94)90372-7
Michael J Lenardo, David Baltimore, None, NF-κB: A pleiotropic mediator of inducible and tissue-specific gene control Cell. ,vol. 58, pp. 227- 229 ,(1989) , 10.1016/0092-8674(89)90833-7
Mark P. Boldin, Igor L. Mett, Eugene E. Varfolomeev, Irina Chumakov, Yonat Shemer-Avni, Jacques H. Camonis, David Wallach, Self-association of the Death Domains of the p55 Tumor Necrosis Factor (TNF) Receptor and Fas/APO1 Prompts Signaling for TNF and Fas/APO1 Effects Journal of Biological Chemistry. ,vol. 270, pp. 387- 391 ,(1995) , 10.1074/JBC.270.1.387
G. Cheng, A. Cleary, Z. Ye, D. Hong, S. Lederman, D. Baltimore, Involvement of CRAF1, a relative of TRAF, in CD40 signaling Science. ,vol. 267, pp. 1494- 1498 ,(1995) , 10.1126/SCIENCE.7533327